Releases Saturday 9 December 2000
No 7274 Volume 321

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(1)  NEW ALZHEIMER'S DRUG WILL BENEFIT
PATIENTS AND CARERS

(2)  SIMPLE PSYCHOLOGICAL TREATMENTS CAN
REDUCE DEPRESSION IN THE COMMUNITY

(3)  LEAGUE TABLES: DOCTORS WARNED TO THINK
AGAIN
 



(1)  NEW ALZHEIMER'S DRUG WILL BENEFIT
PATIENTS AND CARERS

(Efficacy and safety of galantamine in patients with mild to
moderate Alzheimer's disease: multicentre randomised
controlled trial)
http://bmj.com/cgi/content/full/321/7274/1445

Galantamine, a new treatment for Alzheimer's disease, is
effective and well tolerated in patients with mild to moderate
forms of the disease and is associated with significant benefits
on patients' daily living activities, finds a study in this week's
BMJ.

Wilcock and colleagues identified 653 patients with mild to
moderate Alzheimer's disease, attending 86 outpatient clinics
in Europe and Canada. Patients were randomly assigned to
one of two galantamine treatment groups or a placebo group
and were assessed after six months.

The authors found that, compared with placebo, galantamine
significantly improved cognitive function and also slowed the
progression of functional decline (ability to carry out usual
daily activities). For most patients, galantamine was well
tolerated, and the authors believe that the drug will provide
meaningful benefits to patients and carers.

Contact:

Gordon Wilcock, Professor in Care of the Elderly, Frenchay
Hospital, University of Bristol, Bristol, UK Tel:
Email:  Gordon.Wilcock{at}bris.ac.uk
 

(2)  SIMPLE PSYCHOLOGICAL TREATMENTS CAN
REDUCE DEPRESSION IN THE COMMUNITY

(Problem solving treatment and group psychoeducation for
depression: multicentre randomised controlled trial)
http://bmj.com/cgi/content/full/321/7274/1450

As part of a major European study of depression in urban
and rural communities, research in this week's BMJ finds that
two simple psychological interventions are effective in
reducing the severity and duration of depression and
improving mental and social functioning in adults.

Dowrick and colleagues identified 452 adults with depressive
disorders in nine urban and rural communities across Europe.
Participants were randomly assigned to either problem
solving treatment, a course on prevention of depression or
received no treatment (controls), and were assessed at six
and 12 months.

Although problem solving was more acceptable to depressed
people, both interventions were effective in reducing the
severity and duration of depressive disorders and improving
mental and social functioning. At six months, the proportion
of depressed problem solving participants was 17% less than
controls. Similarly, for the depression prevention course, the
difference in proportions of depressed participants was 14%.
By 12 months no significant effects were retained in either
treatment group, but booster sessions might sustain treatment
benefits, suggest the authors.

These findings should influence counselling services and
encourage depressed people to seek psychological help,
conclude the authors.

Contact:

Professor Christopher Dowrick, Department of Primary
Care, University of Liverpool, UK
Email: cfd{at}liv.ac.uk
 

(3)  LEAGUE TABLES: DOCTORS WARNED TO THINK
AGAIN

(School' experience of league tables should make doctors
think again)
http://bmj.com/cgi/content/full/321/7274/1467

A letter in this week's BMJ reports on the dysfunctional
effects of league tables in education and suggests that these
effects may apply to some of the issues surrounding league
tables in the health sector.

Researchers at the University of Durham surveyed heads and
teachers from 54 randomly selected primary schools in
England (with league tables) and Scotland (without league
tables). Not surprisingly they found that, compared with
Scottish schools, English schools were more likely to
concentrate on meeting their targets at the expense of other
important objectives, that target setting had a narrowing effect
on the curriculum and had increased the "blame culture."

What is surprising, say the authors, was the substantially
greater degree of dysfunction reported in English schools than
in Scottish schools, although schools in both countries
seemed to be under similar pressure to meet targets. This
suggests that having league tables does not necessarily apply
greater pressure than other less public techniques, they add.

These findings should give pause for thought, say the authors,
and they warn that careful consideration should be given to
the unintended consequences of league tables.

Contact:

Andy Wiggins (Peter Tymms), University of Durham, UK
Email:  andy.wiggins{at}durham.ac.uk
 
 


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