Releases Saturday 8 December 2001
No 7325 Volume 323

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(1) BABIES BORN DURING SHIFT CHANGES ARE
AT HIGHER RISK OF EARLY DEATH

(2) STUDY SHEDS NEW LIGHT ON LINK
BETWEEN BIRTH WEIGHT, OBESITY, AND
CHILDHOOD GROWTH

(3) SCHIZOPHRENIA RISK HIGHEST IN SMALL
ETHNIC GROUPS

(4) PHARMACISTS CAN CONDUCT EFFECTIVE
CONSULTATIONS WITH PATIENTS

(5) BRITAIN NEEDS MORE PREPARATION FOR
RESPONDING TO PUBLIC HEALTH
EMERGENCIES



(1) BABIES BORN DURING SHIFT CHANGES ARE
AT HIGHER RISK OF EARLY DEATH

(Timing of birth and infant and early neonatal mortality
in Sweden 1973-95: longitudinal birth register study)
http://bmj.com/cgi/content/full/323/7325/1327

Babies born between the hours of 5pm to 1am and
around 9am are at higher risk of early death, suggesting
that shift changes and the hours immediately after are
high risk periods for neonatal care, finds a study in this
week's BMJ.

Using data from the Swedish birth register, researchers
in Hong Kong analysed over 2 million births between
1973-95.

Their observations confirm previous reports that infants
born at night have a greater risk of early death (in the
first six days) than those born during the day. They also
found that there has been no improvement over the past
two decades, and that this problem is much more
serious for preterm infants. The causes are not clear,
but may be due to excess workloads, inadequate or
less experienced staff on night shifts, or out of date
systems for managing shift changes within hospitals, they
suggest.

A more in depth analysis over 24 hours showed that
there were actually two high risk periods for neonatal
care: 5pm to 1am and around 9am. The first risk period
started from the end of the normal day shift and
extended to the midnight shift. The second one, around
9am, was immediately after day shift staff were taking
over responsibilities. This pattern indicates that shift
changes and the hours immediately after are high risk
periods for neonatal care, say the authors.

The exact reasons are unclear, but better vigilance and
an improvement in shift changes may be required to
improve neonatal health care further, they conclude.

Contact:

J Karlberg, Clinical Trials Centre, University of Hong
Kong, People's Republic of China
Email: jpekarl@hkucc.hku.hk

(2) STUDY SHEDS NEW LIGHT ON LINK
BETWEEN BIRTH WEIGHT, OBESITY, AND
CHILDHOOD GROWTH

(Fetal and early life growth and body mass index from
birth to early adulthood in 1958 British cohort:
longitudinal study)
http://bmj.com/cgi/content/full/323/7325/1331

(Editorial: Adult obesity and growth in childhood)
http://bmj.com/cgi/content/full/323/7325/1320
BMJ Volume 323, pp 1320-1

Boys who are light at birth, but then grow rapidly during
childhood, are more likely to be obese as adults, is just
one of the findings from a large study in this week's
BMJ. These potentially complex interrelationships may
hold the key to effective preventive strategies.

Tessa Parsons and colleagues used data collected from
all children born in England, Scotland, and Wales in the
week of 3-9 March 1958 to establish whether birth
weight is related to obesity at different life stages.

Not surprisingly, they found that heavier mothers have
heavier babies and these children tend to become
heavier adults. They also found that rapid growth in
childhood (up to age 7) increased the risk of obesity in
adulthood, especially in men who had been light at birth
or who had thin mothers.

This is an important finding as this pattern of growth is
becoming common in developing countries that are
experiencing a nutritional transition to Western lifestyles,
writes Catherine Law in an accompanying editorial.

Instead of concentrating research efforts on developing
drug treatments for established adult obesity, perhaps
we should use what we know already to design and
evaluate social, behavioural, or policy interventions,
which prevent children from becoming overweight, she
concludes.

Contacts:

Paper: Tessa Parsons, Research Fellow, Institute of
Child Health, London, UK
Email: t.parsons@ich.ucl.ac.uk

Editorial: Catherine Law, Senior Lecturer, MRC
Environmental Epidemiology Unit, University of
Southampton, Southampton, UK
Email: claw@mrc.soton.ac.uk

(3) SCHIZOPHRENIA RISK HIGHEST IN SMALL
ETHNIC GROUPS

(Incidence of schizophrenia in ethnic minorities in
London: ecological study into interactions with
environment)
http://bmj.com/cgi/content/full/323/7325/1336

The rate of schizophrenia among people from non-white
ethnic groups rises as the proportion of these groups fall
in the local population, finds a study in this week's BMJ.

Jane Boydell and colleagues analysed information on all
people from a defined area of south London who had
contact with psychiatric services during 1988-97. They
found that the rate of schizophrenia in non-white ethnic
minorities was highest in those areas where these
minorities comprised a small proportion of the
population and lowest where they comprised a large
proportion.

These findings point towards there being a social cause
for the increased rate of schizophrenia reported in
non-white ethnic groups in the United Kingdom, say the
authors.

Specific stresses for people in ethnic minority groups
could include overt discrimination, institutionalised
racism, alienation, and isolation. The more isolated a
member of an ethnic minority, the more likely he or she
may be to encounter such stresses. People from ethnic
minorities may also be more likely to be singled out or
be more vulnerable when they are in a small minority,
say the authors.

Reduced protection from the effects of such stresses
could be due to decreased social networks or social
buffers in small or dispersed ethnic minority populations,
they conclude.

Contacts:

Jane Boydell, Clinical Researcher, Institute of
Psychiatry, London, UK
Email j.kelly@iop.kcl.ac.uk

or

Robin Murray, Professor of Psychiatry, Institute of
Psychiatry, London, UK
Email: robin.murray@iop.kcl.ac.uk

(4) PHARMACISTS CAN CONDUCT EFFECTIVE
CONSULTATIONS WITH PATIENTS

(Randomised controlled trial of clinical medication
review by a pharmacist of elderly patients on repeat
prescriptions in general practice)
http://bmj.com/cgi/content/full/323/7325/1340

Consultations with a trained pharmacist are an effective
way of reviewing the drug treatment of older patients,
without affecting the workload of general practitioners,
concludes a study in this week's BMJ.

Over 1,000 patients aged 65 or over, who were
receiving at least one repeat medication, were divided
into two groups. The first group was invited to a
consultation at which the pharmacist reviewed their
medical conditions and current treatment. The second
group continued to receive normal care from their
general practitioner and primary healthcare staff.

The pharmacist review resulted in more changes to
treatment and lower prescribing costs than normal care,
without affecting the workload of general practitioners.

Patients seen by the pharmacist were more likely to
have changes made to their repeat prescriptions
because the pharmacist did a more detailed review than
the general practitioner, suggest the authors. This effect
could be important because patient compliance has
been shown to fall with an increasing number of drugs.
Stopping unnecessary drugs may also reduce the risk of
adverse effects and interactions, they add.

The small scale of this trial, involving only four practices,
in one city and just one pharmacist, limits the
generalisability of the results, say the authors.
Nevertheless, it shows that significant and clinically
important results can be achieved by pharmacists
reviewing patients and their treatment.

Contact:

Arnold Zermansky, Honorary Senior Research Fellow,
University of Leeds, UK
Email: arnoldz@easynet.co.uk

(5) BRITAIN NEEDS MORE PREPARATION FOR
RESPONDING TO PUBLIC HEALTH
EMERGENCIES

(Editorial: Managing Major Public Health Crises)
http://bmj.com/cgi/content/full/323/7325/1321

The United Kingdom needs to be better equipped and
organised to deliver health protection in the event of
public health emergencies and major disasters. Though
better prepared than some other countries, many years
of under-investment leaves us vulnerable, warn public
health specialists in this week's BMJ.

The recent terrorist and anthrax attacks in the United
States have shown how all societies need rescue,
health, and public services to respond immediately to
emergencies. The numbers of public health doctors
need to increase, but so do the numbers of non-medical
and nursing staff. The new commitment to public health
from the government and the increased responsibility
given to regions could make this possible if it is
resourced.

Clear guidance is urgently needed if health protection is
to be developed by primary care as it is unclear how
public health staff will be organised when we move into
the new NHS in April 2001. We need in place
mechanisms for immediate release of staff required for
health protection and it must be clear which bodies bear
local responsibility for the control of communicable
disease, say the authors.

For a major emergency in the United Kingdom, some
help could come from continental Europe, in particular
through the European EPIET programme for public
health trainees, add the authors. However the United
Kingdom can and must fundamentally provide health
protection through its own staff who know their locality
and have the confidence of the people.

NHS funding has been increased, but mostly against
specific targets. Recent events make a powerful case
for increasing investment in health protection, they
conclude.

Contact:

Emily Collins, Press Officer, Public Health Laboratory
Service, London, UK
Email: ECollins@PHLS.org.uk


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