Releases Saturday 9 August 2003
No 7410 Volume 327

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(1)  SHORT GAPS BETWEEN PREGNANCIES
LINKED TO COMPLICATIONS

(2)  SUN EXPOSURE SEEMS TO REDUCE RISK OF
MULTIPLE SCLEROSIS

(3)  PRESCRIBING HEROIN CAN HELP TREATMENT
RESISTANT ADDICTS

(4)  SYSTEM FAILURE AT HEART OF CHILD ABUSE
CASE DISASTERS


 

(1)  SHORT GAPS BETWEEN PREGNANCIES
LINKED TO COMPLICATIONS

(Interpregnancy interval and risk of preterm birth and
neonatal death: retrospective cohort study)
http://bmj.com/cgi/content/full/327/7410/313

Women with a very short interval between pregnancies
are at an increased risk of complications such as
premature birth, neonatal death, and low birth weight,
say researchers in this week's BMJ.

The study involved over 89,000 women having second
births in Scotland in 1992-8. Women whose interval
between pregnancies was less than six months were
much more likely to have had complicated first births.
They were also more likely to be less than 20 years old,
to smoke, and to live in an area of high social and
economic deprivation.

Even among women with an uncomplicated first birth,
and after taking account of social and economic factors,
a short interval between pregnancies was associated with
an increased risk of premature birth and neonatal death.

The authors propose that women should be informed of
a small but significantly higher risk of premature birth and
death when they conceive shortly after a birth.

Contraceptive advice should be targeted towards
women who are most likely to have a short
interpregnancy interval, such as teenagers and women
who have lost a newborn baby, they conclude.

Contact:

Professor Gordon Smith, Department of Obstetrics and
Gynaecology, Cambridge University, The Rosie
Hospital, Cambridge, UK
Email: gcss2{at}cam.ac.uk
 

(2)  SUN EXPOSURE SEEMS TO REDUCE RISK OF
MULTIPLE SCLEROSIS

(Past exposure to sun, skin phenotype, and risk of
multiple sclerosis: case-control study)
http://bmj.com/cgi/content/full/327/7410/316

Higher sun exposure during childhood and early
adolescence is associated with a reduced risk of multiple
sclerosis, finds a study in this week's BMJ.

Multiple sclerosis is more common at higher latitudes,
which generally have lower levels of ultraviolet radiation.

The study was carried out in Tasmania, which is located
at high latitude and has a high prevalence of multiple
sclerosis. Researchers surveyed 136 patients with
multiple sclerosis and 272 controls about past sun
exposure, measures to protect against the sun, use of
vitamin D supplements, medical history, and other
factors thought to be associated with multiple sclerosis.
Skin damage and skin colour were also assessed.

They found that higher sun exposure when aged 6-15
years (average 2-3 hours or more a day in summer
during weekends and holidays) and greater skin damage
was associated with a decreased risk of multiple
sclerosis.

Higher exposure in winter seemed more important than
higher exposure in summer and the associations persisted
after adjusting for fair skin and exposure after onset of
disease, say the authors.

They suggest that insufficient ultraviolet radiation or
vitamin D, or both, may influence the development of
multiple sclerosis.

Contacts:

Ingrid van der Mei, PhD student, Menzies Centre for
Population Health Research, University of Tasmania,
Hobart, Australia
Email:  Ingrid.vanderMei{at}utas.edu.au

or

Nick Turner , Corporate Communications
 
 

(3)  PRESCRIBING HEROIN CAN HELP TREATMENT
RESISTANT ADDICTS

(Medical prescription of heroin to treatment resistant
heroin addicts: two randomised controlled trials)
http://bmj.com/cgi/content/full/327/7410/310

Supervised prescription of a combination of methadone
plus heroin is feasible, safe, and effective in reducing the
many physical, mental, and social problems of heroin
addicts, according to Dutch researchers in this week's
BMJ.

Researchers in the Netherlands carried out two separate
trials involving 549 heroin addicts who were not
responding to methadone maintenance treatment. One
trial used inhalable heroin and the other used injectable
heroin.

Participants received either 12 months of methadone
alone (control group), 12 months of methadone plus
heroin (experimental group), or six months of methadone
alone followed by six months of methadone plus heroin
(comparison group). Psychosocial treatment was offered
throughout.

In both trials, 12 month treatment with heroin plus
methadone was significantly more effective than
treatment with methadone alone. Many physical, mental,
and social problems improved and few serious adverse
events occurred.

"Our study provides strong evidence of the efficacy of
prescribed heroin for addicts who are resistant to other
forms of treatment," conclude the authors.

Contact:

Professor Wim van den Brink, Central Committee on the
Treatment of Heroin Addicts (CCBH), Utrecht,
Netherlands
Email: w.vandenbrink{at}amc.uva.nl
 

(4)  SYSTEM FAILURE AT HEART OF CHILD ABUSE
CASE DISASTERS

(Editorial: Suspected child abuse: the potential for justice
to miscarry)
http://bmj.com/cgi/content/full/327/7410/299

System failure lies at the heart of the current crisis
surrounding cases of suspected child abuse, argues a
retired paediatrician in this week's BMJ.

The recent quashing of Sally Clark's conviction for the
murder of two of her children and the collapse of the
case against Trupti Patel have shaken public confidence.
But we need to look less critically at the people caught in
the spotlight, and more at the systems failure involved,
writes Edmund Hey.

Instead, steps to reform the use of expert testimony in
criminal cases and improve pathology services in the UK
would help to minimise potential miscarriages of justice.

Many paediatricians are also becoming increasingly
reluctant to become involved in child protection work for
fear that this will trigger a formal complaint, a disciplinary
hearing, and even litigation, adds the author. There is a
temptation to avoid all involvement and say that these
things are a matter for social services or for the police.
However, he warns that uncertainty as to where prime
responsibility lies has been at the heart of many recent
disasters.

Ultimately it is for the courts to make these difficult
judgements, but they cannot do this without medical
help. Doctors, being human, will sometimes give flawed
advice. There needs to be a robust system in place, in all
our courts, to see that this does not result in a
miscarriage of justice, he concludes.

Contact:

Edmund Hey, Retired Paediatrician, Newcastle, UK
Available by email only: shey{at}easynet.co.uk
 


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