Releases Saturday 14 February 2004
No 7436 Volume 328

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(1) WHAT ARE THE BENEFITS AND HARMS OF
HRT?

(2) PATIENTS SHOULD BE ALLOWED TO PAY FOR
STATINS



(1) WHAT ARE THE BENEFITS AND HARMS OF
HRT?

(Benefits and harms associated with hormone
replacement therapy: clinical decision analysis)
http://bmj.com/cgi/content/full/328/7436/371

(Where are we now with hormone replacement
therapy?)
http://bmj.com/cgi/content/full/328/7436/357

Women free of menopausal symptoms should not use
HRT, but it can help with relief of symptoms, according
to a study in this week's BMJ.

Researchers at Leicester University carried out a clinical
decision analysis on the benefits and harms of HRT,
based on the best currently available evidence. The study
population was white women in the United Kingdom,
aged 50, with or without menopausal symptoms, who
had used combined HRT for five years.

In women free of menopausal symptoms, their analysis
showed a net harm associated with HRT use, which
increased with increasing risk of breast cancer.
However, it showed HRT to be on average beneficial in
women with menopausal symptoms, with benefit
decreasing with increasing risk of breast cancer.

These results agree with the recommendations of the UK
Medicines and Healthcare Products Regulatory Agency,
say the authors. However, overall benefits depend highly
on the severity of symptoms and the associated effect on
quality of life.

As such, they suggest that a decision analysis tailored to
an individual woman is more appropriate in clinical
practice than a population based approach.

Contact:

Keith Abrams, Professor of Medical Statistics,
Department of Health Sciences, University of Leicester,
UK
Email: keith.abrams@le.ac.uk

(2) PATIENTS SHOULD BE ALLOWED TO PAY FOR
STATINS

(Paying for statins)
http://bmj.com/cgi/content/full/328/7436/400

GPs should be able to offer private prescriptions for
cholesterol lowering drugs (statins) to patients below 3%
risk of heart disease, argue researchers in this week's
BMJ.

Statins can help prevent coronary heart disease in people
whose annual risk is 0.6% or more. Yet this would lead
to treatment of over 40% of the British adult population,
and would be unaffordable under the NHS.

Current medical practice therefore recommends
treatment only for those with a risk of over 3% a year,
but this denies effective treatment to 32% of the adult
population.

However, if patients who are currently ineligible for
statins were told that they could benefit from these drugs,
some might be willing to pay for a private prescription,
suggest GP, Nick Raithatha and health economist,
Richard Smith.

They predict that the cost of private treatment with
monitoring by an NHS practice nurse would eventually
be £93.66 a year. This is far less than average household
expenditure on, for example, alcohol (£320), clothes
(£380) and motoring (£920), and may therefore be quite
affordable to people on average earnings.

Although private prescriptions would increase inequality
in access to health care, this is a form of inequality
whereby all members of society gain and is therefore
both economically and ethically jusifiable, they conclude.

Contact:

Annie Ogden, Press Office, University of East
Anglia, UK
Email: press@uea.ac.uk


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